May increase risk of hypotension. Use Caution/Monitor. ------------------------------------------------------------------------- Ferric Carboxymaltose [ Injectafer ] Elemental iron: Injectafer contains 50 mg of elemental iron - 750 mg/15 mL [package insert] Indications: Injectafer is indicated for the treatment of iron deficiency anemia in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron; who have non-dialysis dependent chronic kidney disease. Calcs that help predict probability of a disease, Subcategory of 'Diagnosis' designed to be very sensitive, Disease is diagnosed: prognosticate to guide treatment. Applies only to oral form of both agents. iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Below the form there are further instructions on how to use the calculator. Monitor Closely (1)calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Modify Therapy/Monitor Closely. Many patients with kidney disease cannot get enough iron from food and require injections. Controlled studies in pregnant women show no evidence of fetal risk. Anemia. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Applies only to oral form of both agents. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. iron sucrose increases levels of calcium citrate by enhancing GI absorption. restrictions. Deferoxamine chelates iron. Administer Injectafer intravenously, either as an undiluted slow intravenous push or by infusion. Use Caution/Monitor. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. Read our. We comply with the HONcode standard for trustworthy health information. For liquid medications, also enter the value of the Medicine Concentration and choose . Iron sucrose (Venofer) 100 mg/5 mL vial 200 - 300 mg given every 3-7 days 300 mg doses are given over 90 minutes 500 mg/dose. In post-marketing safety studies of Venofer in 1,051 patients with HDD-CKD, adverse reactions reported by >1% were cardiac failure congestive, sepsis and dysgeusia. 4)Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Where C= concentration of vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. Contraindicated. Divide the calculated dose by the patient's weight (IBW if BMI >30, or actual body weight (ABW) if BMI30) to ensure it does NOT exceed 20mg/kg. Administer a test INFeD dose prior to the first therapeutic dose. nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. ]Venofer treatment may be repeated if iron deficiency reoccurs. Fulminant symptoms may include general paleness, confusion or episodes of passing out. Parenteral iron supplementation. This drug is available at the lowest co-pay. Use INFeD only in patients in whom clinical and laboratory investigations have established an iron deficient state not amenable to oral iron therapy. Avoid or Use Alternate Drug. Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). Use Caution/Monitor. Administer on 5 different occasions over a 14 day period. 2 DOSAGE & ADMINISTRATION Venofer must only be administered intravenously either by slow injection or by infusion. Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. For all products, slow initial infusion is prudent; the patient is observed closely for infusion reactions. Corrected Sodium and Effective Osmolality. Applies only to oral form of both agents. Your doctor will do laboratory tests to monitor your response. Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland. Modify Therapy/Monitor Closely. Use Caution/Monitor. Monitor Closely (1)cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Copyright(c) 2023 First Databank, Inc. Avoid or Use Alternate Drug. pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Contraindicated. Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. Avoid or Use Alternate Drug. Minor/Significance Unknown. Monitor Closely (1)lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Minor/Significance Unknown. This website is intended for use by US healthcare professionals only. US residents can call their local poison control center at 1-800-222-1222. IDA diagnosis is based on full blood examination and on the serum ferritin level. iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. Reactions have occurred following the first dose or subsequent doses of Venofer. Observed Hb = the patients current hemoglobin in g/dl. Crown Rump Length and Nuchal Translucency. Indications: Ferrlecit is an iron replacement product for treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. This calculator will help pinpoint potential causes of anemia based on Separate by at least 4 hours. Intravenous iron-dextran: therapeutic and experimental possibilities. Use Caution/Monitor. The factor 2.4 is derived from the following assumptions: a) Blood volume 70 ml/kg of body weight ~7% of body weight b) Iron content of hemoglobin 0.34% Factor 2.4 = 0.0034 x 0.07 x 10000 (conversion for g/dL) Ganzoni AM. Methods: We reviewed the experience of our department between January, 2011 and February, 2014 with the use of intravenous iron sucrose in children 14 years of age who failed in oral iron therapy for iron deficiency anemia (IDA). Applies only to oral form of both agents. didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. You will have to pay for your IV iron. Venofer can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. Replacement of iron stores found in hemoglobin, myoglobin, and enzymes; works to transport oxygen via hemoglobin, Do not mix with other medications or add to parenteral nutrition solutions for IV infusion, Do not dilute to concentrations below 1 mg/mL, Add dose to 0.9% NaCl infusion bags (PVC or non-PVC); final concentrations range is 1-2 mg of elemental iron/mL, Visually inspect for particulate matter and discoloration prior to infusion, Stable for 7 days at controlled room temperature (25C). Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Medically reviewed by Drugs.com. Interaction only with oral iron administration. Before using, check this product visually for particles or discoloration. Found in multiple references. commonly, these are "non-preferred" brand drugs. Oral and parenteral products - see background option for oral products. Applies only to oral form of both agents. Steps on how to print your input & results: 1. Transferrin saturation (TSAT) values increase rapidly after intravenous administration of iron sucrose; do not perform serum iron measurements for at least 48 hours after intravenous dosing. Applies only to oral form of both agents. Venofer must only be administered intravenously either by slow injection or by infusion. Hanson DB, Hendeles L. Guide to total dose intravenous iron dextran therapy. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. commonly, these are "preferred" (on formulary) brand drugs. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmVub2Zlci1pcm9uLXN1Y3Jvc2UtMzQyMTYy, View explanations for tiers and Serious - Use Alternative (1)iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Use Caution/Monitor. Methods. Adult Patients: The most common adverse reactions (2%) include diarrhea, nausea, vomiting, headache, dizziness, hypotension, pruritus, pain in extremity, arthralgia, back pain, muscle cramp, injection site reactions, chest pain and peripheral edema. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Applies only to oral form of both agents. Slowing the infusion rate may alleviate symptoms. Applies only to oral form of both agents. Applies only to oral form of both agents. Venofer treatment may be repeated if iron deficiency reoccurs. Use alternatives if available. Applies only to oral form of both agents. sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. iron sucrose decreases levels of deferiprone by enhancing GI absorption. Treatment of anemia due to iron deficiency. You may report side effects to Health Canada at 1-866-234-2345. Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. iron sucrose decreases levels of manganese by inhibition of GI absorption. Hemodialysis-dependent: 0.5 mg/kg IV q2weeks for 12 weeks; not to exceed 100 mg/dose, Non-dialysis dependent or peritoneal-dependent (on erythropoietin): 0.5 mg/kg IV q4weeks for 12 weeks; not to exceed 100 mg/dose, sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate, Serious hypersensitivity reactions reported, including anaphylactic-type reactions, some of which have been life-threatening and fatal, Patients may present with shock, clinically significant hypotension, loss of consciousness, and/or collapse, If hypersensitivity reactions or signs of intolerance occur during administration, stop infusion immediately, Monitor patients for signs and symptoms of hypersensitivity during and after administration for at least 30 minutes and until clinically stable following completion of the infusion, Animal reproduction studies of iron sucrose administered to rats and rabbits during period of organogenesis at elemental iron doses equivalent to maximum recommended human dose based on body surface area revealed no evidence of harm to the fetus; adverse outcomes in pregnancy occur regardless of health of mother or use of medications, Iron deficiency anemia during pregnancy should be treated; untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia; adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight, HD-dependent and non-dialysis-dependent CKD: Dilute with up to 100 mL of 0.9% NaCl, PD-dependent CKD: Dilute with up to 250 mL of 0.9% NaCl, Undiluted: Administer by slow IV injection over 2-5 min, Diluted solutions: Administer IV over 15 min, Undiluted: Administer by slow IV injection over 5 minutes, Diluted solutions: Administer IV over 5-60 minutes, Store in original carton at 20-25C (68-77 F); excursions permitted to 15- 30C (59-86F), Syringe: Store at room temperature (25C) or under refrigeration (4C) for up to 7 days, IV infusion: Store at room temperature (25C) for up to 7 days. Use Caution/Monitor. Applies only to oral form of both agents. Option 2: 200 mg in NS 100 mL administered over 20-30 minutes; may repeat every other day to 0.5 mg/kg (not to exceed 100 mg/dose) diluted to a concentration of 1 to 2 mg/mL in 0.9% sodium chloride IV over 5 to 60 minutes Administer every 4 weeks for 12 weeks Do not dilute to concentrations below 1 mg/mL Comments: Treatment may be repeated if necessary. Applies only to oral form of both agents. Schrier SL, Mentzer WC, Landaw SA. Iron Deficiency In Pregnancy Calculator, Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator. FOR PATIENTS WEIGHING 50 kg OR MORE: Administer 1000 mg of Monoferric by intravenous infusion 20 minutes as a single dose 1. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. View the formulary and any restrictions for each plan. In less advanced cases of iron deficiency, increases in dietary intake of iron may be sufficient. . Minor/Significance Unknown.iron sucrose increases levels of calcium acetate by enhancing GI absorption. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Pain, swelling, or redness at the injection site may occur. World J Gastroenterol; 16(22): 27202725. Applies only to oral form of both agents. The dosing for iron replacement treatment in pediatric patients with Peritoneal or Hemodialysis-Dependent - CKD or Non-Dialysis Dependent CKD have not been established. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Applies only to oral form of both agents. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Last updated on Jun 1, 2022. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abacb7fa-2fc2-471e-9200-944eeac8ca2a. If we don't have the calculator you need then tell us the details and we'll make it for you. STORAGE: Consult the product instructions and your pharmacist for storage details. Minor/Significance Unknown. Avoid or Use Alternate Drug. Minor/Significance Unknown. . Use Caution/Monitor. Monitor Closely (1)omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. *Administer early during the dialysis session. Copyright 1993-2021 By clicking send, you acknowledge that you have permission to email the recipient with this information. If dose exceeds 20mg/kg it should be rounded down to 20mg/kg OR administration of the total dose has to be split and given 7 days apart. iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Either increases effects of the other by pharmacodynamic synergism. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] -Volume of parenteral iron product req'd (mL) = [Iron deficit (mg)] / C(mg/mL) Final calculations: -Hgb iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) -Volume of product required (mL) = [weight (kg)x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. commonly, these are generic drugs. Venofer [package insert]. 4. Medicinal forms Either increases effects of the other by pharmacodynamic synergism. Venofer treatment may be repeated if iron deficiency reoccurs. 1. Applies only to oral form of both agents. Fatal reactions have followed the test dose of iron dextran injection. Ferumoxytol [ Feraheme ] Elemental iron: 510 mg/17 mL (17 mL) 30 mg/mL [package insert] - Boxed warning REVIEW INSERT. Minor/Significance Unknown. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. Where: Medicine concentration Amount of active substance per a given volume of your drug. Kumpf VJ, Holland EG. Get in touch with MDApp by using the following contact details: 2017 - 2023 MDApp. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hemoglobin conc. Use Caution/Monitor. J Lab Clin Med. Ferritin and transferrin are also recommended monitoring . Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. Challenges in the treatment of iron deficiency include finding and addressing the underlying cause and the selection of an iron replacement product that meets the needs of the patient. This cost includes the fee charged by the pharmacy. This health tool computes the iron deficit based on patient parameters and the Ganzoni formula. Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. HOW TO USE: This medication is given by injection into a vein as directed by your doctor. Venofer is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Otherwise, call a poison control center right away. Consult your pharmacist or local waste disposal company. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. It is important to note that the above calculations merely provide estimates and that individual dosage should be established by a medical professional based on the current package insert for the elemental iron product used. 1) Ganzoni AM. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . Iron supplements, regardless of their way of administration, are used to replete body stores and to correct anemia. This iron deficiency calculator determines the iron deficit based on patient weight, hemoglobin and iron stores to prepare for iron replacement.
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