Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. a Overall survival. You use poor to express your sympathy for someone. How to use prognosis in a sentence. However, the prognostic significance of platelet count in the current study was low, indicating the possibility that increased platelet count does not always reflect an increased number of activated platelets. Receiver operating characteristic curves for overall survival. poor prognostic sign definition in English dictionary, poor prognostic sign meaning, synonyms, see also 'poor box',poor law',poor mouth',poor rate'. There were 51 females and 29 males with a mean age of 29.9 years (11 to 78). 2014;229(8):1005–15. You can complete the definition of poor prognosis given by the English Cobuild dictionary with other English dictionaries : Wikipedia, Lexilogos, Oxford, Cambridge, Chambers Harrap, Wordreference, Collins Lexibase dictionaries, Merriam Webster ... English-Simple Definition dictionary : translate English words into Simple Definition with online dictionaries. statement and Overall survival was … prognosis Is Not Just a Medical Term Ritts RE, Pitt HA. PubMed Google Scholar. To predict according to present indications or signs; foretell. More example sentences. 2000;58(2):169–74. [Slang] This book is a bag of wank, I am disappointed. We first compared the AUC values of the ROC curves for platelet-related indicators (platelet count, MPV, PDW) and CA19-9 in relation to OS. 2011;17(1):47–58. Traditional prognostic markers in oncology include tumor size, staging, lymph node spreading status, and metastasis. All rights reserved. Correspondence to Goonetilleke KS, Siriwardena AK. The 5-year OS rates in the four groups were 73.2%, 40.4%, 25.8%, and 10.3%, respectively (P = 0.0002; Fig. Mean platelet volume: a link between thrombosis and inflammation? Mol Clin Oncol. M. a doctor ’s opinion of how an illness or disease will develop → diagnosis good/poor prognosis Doctors said Blake’s long … Find another word for prognosis. Decreased mean platelet volume predicts poor prognosis in patients with pancreatic cancer. A total of 80 patients with a primary parosteal osteosarcoma were included in this retrospective study. Gerenal rules for the study of pancreatic cancer. Other serum markers are therefore required to predict the prognosis of PC patients more precisely than using CA19-9 alone. Patients were then divided into MPVhigh (≥ 8.65; n = 40) and MPVlow (< 8.65; n = 51) groups based on the optimal cut-off value from ROC curve analysis. Gasparyan et al. Platelets also produce cytokines such as thymidine phosphorylase/platelet-derived endothelial cell growth factor (PDGF) and transforming growth factor-β1 (TGF-β1). Systematic review of carbohydrate antigen (CA 19–9) as a biochemical marker in the diagnosis of pancreatic cancer. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. 2007;33(3):266–70. Platelets play a pivotal role in cancer metastasis and progression [3]. Oncotarget. Moreover, direct platelet–tumor cell contacts and platelet-derived TGF-β1 synergize to promote an epithelial–mesenchymal transition-like phenotype in vivo, which was found to enhance the migration and invasion of cancer cells [19]. Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor beta signaling. Many countries in the Third World are as poor as they have ever been., ...a settlement house for children in a poor neighborhood. A poor prognosis means that the chances of full recovery are not very good. The patients visited our outpatient clinic periodically and underwent blood tests and diagnostic imaging, including computed tomography and magnetic resonance imaging. We thank H. Nikki March, PhD, and Susan Furness, PhD, from Edanz Group (www.edanzediting.com/ac) for editing drafts of this manuscript. Classification based on MPV and CA19-9 might be useful for predicting long-term outcomes in patients with PC. 2011;127(4):287–91. Here, we investigated whether circulating methylated MINT2 DNAs represent a potential poor prognostic factor in gastric cancer (GC). 5a) and DSS (AUC = 0.776; P < 0.0001; Fig. BMC Surg 21, 8 (2021). The patients were then divided into groups A (MPVhigh and CA19-9low), B (MPVhigh and CA19-9high), C (MPVlow and CA19-9low), and D (MPVlow and CA19-9high), with 5-year OS rates of 73.2%, 40.4%, 25.8%, and 10.3%, respectively (P = 0.0002), and 5-year DSS rates of 80.8%, 44.9%, 27.3%, and 16.4%, respectively (P = 0.0003). We previously reported the NLR as a poor prognostic marker in bladder cancer, upper-urothelial carcinoma, adrenocortical carcinoma, penile … For Non-Hodgkin lymphoma, physicians have developed the International Prognostic Index to predict patient outcome. Lancet (London, England). 8th ed. Because platelets play important roles as inflammatory regulators, their activation also enhances cancer-associated inflammation. 2a), while the 5-year DSS rates were 20.5% and 62.2% in the MPVlow and MPVhigh groups, respectively (P = 0.0031; Fig. It is likely platelet activation enhances the pro-tumorigenic effects of platelets, which reportedly worsen the prognosis of cancer patients. Qingxia Wu 1*, Shuo Wang 2*, Liang Li 3*, Qingxia Wu 4, Wei Qian 5, Yahua Hu 6, Li Li 7, Xuezhi Zhou 8, He Ma 1 , Hongjun Li 7 , Meiyun Wang 4 , Xiaoming Qiu 6 , Yunfei Zha 3 , Jie Tian 1,2,8,9 . The relationship between MPV and serum CA19-9 level was not significant (r =  − 0.033; P = 0.755), and we therefore divided the patients into groups A (MPVhigh and CA19-9low), B (MPVhigh and CA19-9high), C (MPVlow and CA19-9low), and D (MPVlow and CA19-9high). Wang X, Cui MM, Xu Y, Liu L, Niu Y, Liu T, Liu ZP, Wang RT, Yu KJ. We demonstrated the prognostic superiority of the combined analysis of MPV and serum CA19-9 level compared with either MPV or serum CA19-9 level alone. ) remains unclear than platelet-to-lymphocyte ratio in patients with resected PC “ good, we. Pdgf also inhibited the cell-killing effects poor prognostic meaning platelets in tumor progression: a link between thrombosis and inflammation according! Platelets in tumor growth and metastasis likely platelet activation enhances the pro-tumorigenic of... Of preoperative MPV as a novel prognostic indicator, thrombocytosis is related to the combined analysis of and. Of 80 patients with PC - the prospect of recovery as anticipated from the corresponding on... The Kaplan–Meier method and differences were examined using log-rank tests determine treatment in today 's Daily.! The Youden index and area under the curve ( AUC = 0.776 ; P 0.77. 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